The Codon Table for the MCAT: Decode Protein Synthesis with Confidence

You’ll almost definitely encounter questions on DNA, RNA, and protein synthesis on the MCAT. The codon table—used to translate mRNA into amino acid sequences—is one of the most high-yield visuals you can memorize for exam day.

Thanks to this clear and color-coded King of the Curve visual, decoding a protein just became a lot easier.

🧬 What Is the Codon Table?

The codon table maps mRNA sequences (codons) to their corresponding amino acids, guiding the formation of polypeptides during translation.

Each codon is made of 3 RNA bases (A, U, C, G) and corresponds to one amino acid—or a stop signal.

Key Codons to Know for the MCAT

Codon Function
AUG Start codon (also codes for methionine)
UAA, UAG, UGA Stop codons (signal termination of translation)

🧠 MCAT Tip: Don’t just memorize codons—practice reading the table and identifying start/stop sequences in the context of mRNA strands.

How to Read the Table

  • Start with the first letter (left column)

  • Move to the second letter (top row)

  • Use the third letter (right column) to pinpoint the amino acid

Example:
Codon = AUG
A (1st letter, left side) → U (2nd letter, top) → G (3rd letter, right)
Result = Methionine (Start)

Why the Codon Table Matters on the MCAT

It’s tested in questions that ask you to:

  • Translate mRNA sequences into amino acid chains

  • Recognize start and stop codons

  • Predict mutations and their consequences (e.g., silent vs nonsense mutations)

  • Distinguish coding vs template strands of DNA

MCAT-Style Question Example

Question:
Which of the following mRNA sequences contains a premature stop codon?

A. AUG-GCC-CGU-UGA
B. AUG-GGU-ACC-GCU
C. AUG-CGC-GGC-UUA
D. AUG-UGU-UUC-CAA

Correct Answer: AUGA is a stop codon, which truncates the protein early.

Final Thoughts

The codon table is more than just a chart—it’s your translation key to understanding gene expression and mutations on the MCAT. With King of the Curve’s visual, this complex concept becomes second nature.

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